Opinion Article by Charles Maack
The information in this article is a lengthy read, but for men moved to androgen deprivation therapy the information is extremely important to be aware since everything explained may be involved in their well-being.
Triple-hormonal blockade/androgen deprivation therapy (ADT3) includes the prescribing of:
- a LHRH/GnRH agonist or antagonist to shut down testicular testosterone production
- an antiandrogen to block testosterone access to the cancer cell nucleus
- a 5Alpha Reductase (5AR) inhibitor to prevent any testosterone that might access the cancer cell nucleus from converting to dihydrotestosterone/DHT
Read the entire article on oncogen.org HERE
Don’t get confused with all the various prostate cancer terms and drugs. The following resources can help you with these. You can also find these links in the Resources section of this website.
PCF has updated it’s 2019 Patient Guide. Compiled with the contributions of top-tier doctors and researchers in prostate cancer, it is a must-have resource for patients and families. It focuses all of the information available about contemporary prostate cancer research, treatment, and lifestyle factors into one consolidated document.
Get it HERE.
As many as 40% of newly diagnosed PCa patients have unifocal disease, that is, just one focus of cancer. But that still leaves 60-80% of patients with multifocal PCa. Without evidence to the contrary, multiple foci in the same gland were thought to be biologically homogeneous, that is, identical to each other.
Then, along came the tools to analyze PCa at the molecular level, bringing new knowledge of the biology of PCa.
Read about this by clicking here.
If you experience a frequent urge to urinate—perhaps due to having an enlarged prostate if you’re a man, having given birth if you’re a woman, or having an “overactive bladder”—there may be a practical do-it-yourself solution to the problem, referred to as bladder training. It’s worth a try before resorting to medication or surgical procedures.
Read more at berkeleywellness.com HERE
Stereotactic body radiation therapy or SBRT (sometimes referred to as Cyberknife or SHARP) has had excellent 7-year outcomes in an update of the consortium study, including data from 10 single-institution trials and two multi-institutional trials. Get the details HERE.
Men who are initially diagnosed with intermediate-risk prostate cancer may or may not be good candidates for Active Surveillance. This excellent article begins to provide a basis for making that determination. You can read the article by clicking HERE.
Moderately hypofractionated IMRT (radiation therapy delivered in 20 to 26 treatments instead of the conventional 40-44 treatments) has received strong endorsement from all of the major US organizations of physicians who treat prostate cancer. Read more about this significant new guideline here.
Scientists at Cedars-Sinai have discovered how prostate cancer can sometimes withstand and outwit a standard hormone therapy, causing the cancer to spread. Their findings also point to a simple blood test that may help doctors predict when this type of hormone therapy resistance will occur. Learn more about these interesting findings by clicking HERE.
So you’ve had your PSA test, and it came back high. Your doctor did a DRE and ran a few more tests, and assures you that prostate cancer is very unlikely. Still, you’re worried. What are some other causes of a high PSA?
Read about this in the Prostate Care Foundation blog HERE